Junan Li, PhD

Li
Research Assistant Professor
Environmental Health Sciences

333 W. 10th Ave
3160 Graves Hall
Columbus, OH 43210
Send Email
Phone: (614) 292-4168

 

Education

Ph.D., Biochemistry, The Ohio State University, 2000
M.S., Biochemistry, Peking University, Beijing, China, 1992
B.S., Biology, Peking University, Beijing, China, 1989

Appointments

Assistant Professor, Division of Environmental Health Sciences, The Ohio State University
Member, American Association of Cancer Research
Member, American Chemical Society
Member, Phi Kappa Phi
Member, Federation of Asian and Oceanic Biochemists

 

Research

Structure-function relationship of tumor suppressor proteins

The role of oncogenic gankyrin in the development of human oral cancers

The coordination of CDK4-modulating proteins in human tumors

 

2008 Publications

Junan Li, Blake Warner, Bruce, C. Casto, Thomas, J. Knobloch, and Christopher, M. Weghorst. Tumor suppressor p16INK4A/Cdkn2a alterations in 7, 12-dimethylbenz (a) anthracene (DMBA)-induced hamster cheek pouch tumors. Mol. Carcinogenesis 47, 733-738 (2008) (Corresponding author).

Peter Muscarella, Mark Bloomston, Alexander, R. Brewer, Anjali Mahajan, Wendy, L. Frankel, E. Christopher Ellison, William, B. Farrar, Christopher, M. Weghorst, and Junan Li. Expression of the p16INK4A/Cdkn2a gene is prevalently down-regulated in human pheochromocytoma tumor specimens. Gene Expression 14, 207-216 (2008) (Corresponding author).

Laura, A. Kresty, Susan, R. Mallery, Thomas, J. Knobloch, Junan Li, Mary Lloyd, Bruce, C. Casto, and Christopher, M. Weghorst. Frequent alterations of p16INK4a and p14ARF in oral proliferative verrucous leukoplakia. Cancer Epidemiology Biomarkers & Prevention 17, 3179-3187 (2008).

 

2007 Publications

Anjali Mahajan, Yi Guo, Chunhua Yuan, Christopher, M. Weghorst, Ming-Daw Tsai, Junan Li. Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and p16. Journal of Molecular Biology 2007, [Epub ahead of print].

Lin, Y.C., Diccianni, M. B., Kim, Y., Lin, H. H., Lee, C. H., Lin, R. J., Joo, S.-H., Li, J., Chuang, T. J., Yang, A. S., Kuo, H. H., Tsai, M.-D., Yu, A. L. Human p16gamma, a novel transcriptional variant of p16(INK4A), coexpresses with p16 (INK4A) in cancer cells and inhibits cell-cycle progression. Oncogene 2007, [Epub ahead of print].

 

2006 Publications

Junan Li, Anjali Mahajan, Ming-Daw Tsai. Ankyrin repeat: a unique motif mediating protein-protein interactions. Biochemistry 45, 15168-15178 (2006).

Junan Li, Jiuxiang Zhu, W. Scott Melvin, Tanios S. Bekaii-Saab, Ching-Shih Chen, Peter Muscarella. A structurally optimzed Celecoxib derivative inhibits human pancreatic cancer cell growth. Journal of Gastrointestinal Surgery 10, 206-213 (2006).