Chris Weghorst, PhD

Weghorst
Professor
Environmental Health Sciences

300 W. 10th Ave.
Room 1148A
Columbus, OH 43210
Send Email
Phone: (614) 293-6063

 

Education

1989 Ph.D. Biomedical Sciences (Pathology), Medical College of Ohio, Toledo, Ohio
1984 B.A. Biology, Mount Vernon Nazarene University, Mount Vernon, Ohio

Appointments

American Association for Cancer Research
Society of Toxicology

 

Courses

Principles of Environmental Health (PEP)
Molecular Techniques for EHS

 

Research

Molecular Events in Progression/Prevention of Oral Cancer”/Project 3 “Inactivation of the TGFß Receptor Complex in Oral Cancer Development

Prevention of Experimental Oral Cancer by Topical Application of Natural Food Products

Chemoprevention Screening in Mutant Mouse Models by Agents that Inhibit Inflammation

Chemopreventive Agent-Responsive Genes in Oral Cancer

Apoptotic Mechanisms of NSAID Chemoprevention

 

2008 Publications

Kresty LA, Mallery SR, Knobloch TJ, Li J, Lloyd M, Casto BC, Weghorst CM. Frequent Alterations of p16INK4a and p14ARF in Oral Proliferative Verrucous Leukoplakia. Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3179-87.

Li J, Warner B, Casto BC, Knobloch TJ, Weghorst CM. Tumor suppressor p16(INK4A)/Cdkn2a alterations in 7, 12-dimethylbenz(a)anthracene (DMBA)-induced hamster cheek pouch tumors. Mol Carcinog. 2008 Oct;47(10):733-8.

 

2007 Publications

Bian Y, Knobloch TJ, Sadim M, Kaklamani V, Raji A, Yang GY, Weghorst CM, Pasche B. Somatic acquisition of TGFBR1*6A by epithelial and stromal cells during head and neck and colon cancer development. Hum Mol Genet. 2007 Dec 15;16(24):3128-35. Epub 2007 Sep 21. PMID: 17890272 [PubMed - in process]

Mahajan A, Guo Y, Yuan C, Weghorst CM, Tsai MD, Li J. Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16. J Mol Biol. 2007 Nov 2;373(4):990-1005. Epub 2007 Aug 22. PMID: 17881001 [PubMed - in process]