Title: Public participation/community involvement activities project of local and state environmental health programs
Sponsor: Charles F. Kettering Foundation
Description: A survey to measure public participation activities and interest of local environmental health programs within local health departments.
Faculty: Pompili (Principal Investigator)
Title: Molecular Events in Progression/Prevention of Oral Cancer”/Project 3 “Inactivation of the TGF-beta Receptor Complex in Oral Cancer Development
Sponsor: National Institute of Dental and Craniofacial Research/NIH
Description: The major goal of this project is to investigate the role that inactivation of the TGF-beta receptor plays in the multi-stage deregulation of the cell cycle leading to uncontrolled cell proliferation
Faculty: Weghorst (project #3 leader)
Award P.I.: Stoner
Title: Prevention of Experimental Oral Cancer by Topical Application 10% of Natural Food Products
Sponsor: Cancer Research Foundation of America
Description: Determine the ability of natural food products, black raspberries and curcumin to inhibit oral cancer in the hamster cheek pouch model using topical application of chemopreventive agents after tumor initiation.
Faculty: Weghorst (Principal Investigator)
Research staff: Casto (Co-Investigator)
Title: Chemopreventive screening in mutant mouse models by agents which inhibit inflammation
Sponsor: National Cancer Institute/NIH
Description: The major goals of this project are to establish a breeding colony of mutant mice (p53, Kras, and p16) sufficient to carry out chemoprevention experiments and test the chemopreventive efficacy of agents using tobacco-smoke induced lung tumorigenesis models in A/J mice bearing alterations to the above tumor suppressor genes.
Faculty: Weghorst (Principal Investigator)
Title: Chemopreventive agent-responsive genes in oral cancer
Sponsor: National Institute of Dental and Craniofacial Research/NIH
Description: The major goals of this project are to examine the temporal and dose effects of various black raspberry components and extracts on gene expression in normal, premalignant and malignant cells in vitro and in vivo.
Faculty: Weghorst (Principal Investigator)
Research staff: Knobloch (Co-Investigator)
Title: Apoptotic Mechanisms of NSAID Chemoprevention
Sponsor: NIH/NCI
Description: The major goals of this project are to use pharmacological and genomic approaches to define the molecular targets in signaling pathways to agent-induced mitochondrial membrane instability, apoptosis, and growth inhibition
Faculty: Weghorst (Co-Principal Investigator)
Research staff: Casto (Co-Investigator)
