Double Negative Control Inference in Test-Negative Design Studies of Vaccine Effectiveness Joint work with Qijun (Kendrick) Li, Wang Miao, and Eric Tchetgen Tchetgen
The test-negative design (TND) has become a standard approach to evaluate vaccine effectiveness. Despite TND's potential to reduce unobserved differences in healthcare-seeking behavior (HSB) between vaccinated and unvaccinated subjects, it remains subject to various potential biases. First, residual confounding bias may remain due to unobserved HSB, occupation as a healthcare worker, or previous infection history.
