Associate Dean for Research and Professor
Administration
Environmental Health Sciences
Phone:
614-247-4942
Email:
weghorst.2@osu.edu
1841 Neil Ave.
258 Cunz Hall
Columbus, OH, 43210
Research Interests:
Molecular mechanisms of oral carcinogenesis and prevention
Education:
1989 Ph.D. Biomedical Sciences (Pathology), Medical College of Ohio, Toledo, OH
1984 B.A. Biology, Mount Vernon Nazarene University, Mount Vernon, OH
Courses:
Directs: PUBHEHS6300 and PUBHEHS6315
Co-Directs: PUBHEHS8340
Awards/Honors:
V Foundation Scholar, The V Foundation for Cancer Research, Cary, NC
American Cancer Society Research Scholar, The American Cancer Society, Atlanta, GA
Selected Publications:
Poi MJ, Knobloch TJ, Yuan C, Tsai MD, Weghorst CM, Li J. Evidence that P12, a specific variant of P16(INK4A), plays a suppressive role in human pancreatic carcinogenesis. Biochem Biophys Res Commun. 2013 Jun 28;436(2):217-22. doi: 10.1016/j.bbrc.2013.05.078. Epub 2013 May 29. PubMed PMID: 23727582.
Yuan C, Guo Y, Zhu L, Guo W, Mahajan A, Weghorst CM, Li J. The Study ofpH-Dependent Stability Shows that the TPLH-Mediated Hydrogen-Bonding Network Is Important for the Conformation and Stability of Human Gankyrin. Biochemistry. 2013 Jul 8. [Epub ahead of print] PubMed PMID: 23777370.
Pereira MA, Warner BM, Knobloch TJ, Weghorst CM, Lubet RA, Steele VE, Casto BC. Chemoprevention of mouse lung and colon tumors by suberoylanilide hydroxamic acid and atorvastatin. Int J Cancer. 2012 Sep 15;131(6):1277-86. doi: 10.1002/ijc.27395. Epub 2012 Jan 31. PubMed PMID: 22161747.
Li J, Knobloch TJ, Poi MJ, Zhang Z, Davis AT, Muscarella P, Weghorst CM. Genetic alterations of RD(INK4/ARF) enhancer in human cancer cells. Mol Carcinog. 2012 Oct 12. doi: 10.1002/mc.21965. [Epub ahead of print] PubMed PMID: 23065809.
Accurso BT, Warner BM, Knobloch TJ, Weghorst CM, Shumway BS, Allen CM, Kalmar JR. Allelic imbalance in oral lichen planus and assessment of its classification as a premalignant condition. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Sep;112(3):359-66.
Zhang Z, Knobloch TJ, Seamon LG, Stoner GD, Cohn DE, Paskett ED, Fowler JM, Weghorst CM. A black raspberry extract inhibits proliferation and regulates apoptosis in cervical cancer cells. Gynecol Oncol. 2011 Nov;123(2):401-6. doi: 10.1016/j.ygyno.2011.07.023. Epub 2011 Aug 9. PubMed PMID: 21831414.
Li J, Knobloch TJ, Kresty LA, Zhang Z, Lang JC, Schuller DE, Weghorst CM. Gankyrin, a biomarker for epithelial carcinogenesis, is overexpressed in human oral cancer. Anticancer Res. 2011 Sep;31(9):2683-92.
Casto BC, Sharma S, Fisher JL, Agrawal A, Weghorst CM. Oral cancer in Appalachia. J Health Care Poor Underserved. Feb;20(1): 2009. 274-85.
Muscarella P, Bloomston M, Brewer AR, Mahajan A, Frankel WL, Ellison EC, Farrar WB, Weghorst CM, Li J. Expression of the p16INK4A/Cdkn2a gene is prevalently downregulated in human pheochromocytoma tumor specimens. Gene Expr. 2008;14(4):207-16. PubMed PMID: 19110720.
Li J, Warner B, Casto BC, Knobloch TJ, Weghorst CM. Tumor suppressor p16(INK4A)/Cdkn2a alterations in 7, 12-dimethylbenz(a)anthracene (DMBA)-induced hamster cheek pouch tumors. Mol Carcinog. 2008 Oct;47(10):733-8.
Kresty LA, Mallery SR, Knobloch TJ, Li J, Lloyd M, Casto BC, Weghorst CM. Frequent Alterations of p16INK4a and p14ARF in Oral Proliferative Verrucous Leukoplakia. Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3179-87.
Bian Y, Knobloch TJ, Sadim M, Kaklamani V, Raji A, Yang GY, Weghorst CM, Pasche B. Somatic acquisition of TGFBR1*6A by epithelial and stromal cells during head and neck and colon cancer development. Hum Mol Genet. 2007 Dec 15;16(24):3128-35. Epub 2007 Sep 21. PMID: 17890272 PubMed - in process
Pasche B, Knobloch TJ, Bian Y, Liu J, Phukan S, Rosman D, Kaklamani V, Baddi L, Siddiqui FS, Frankel W, Prior TW, Schuller DE, Agrawal A, Lang J, Dolan ME, Vokes EE, Lane WS, Huang CC, Caldes T, Di Cristofano A, Hampel H, Nilsson I, von Heijne G, Fodde R, Murty VV, de la Chapelle A, Weghorst CM. Somatic acquisition and signaling of TGFBR1*6A in cancer. JAMA. 2005 Oct 5;294(13):1634-46. PubMed PMID: 16204663.
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