En Huang, PhD
Associate Professor
Environmental Health Sciences
“I’m passionate about public health because improving food safety and addressing antibiotic resistance can make a real difference in people’s everyday lives. I’m especially motivated by translating discoveries from my lab into strategies that prevent illness and preserve the effectiveness of antibiotics now and in the future.”
Biography
Dr. Huang’s research is dedicated to advancing public health through the mitigation of risks posed by foodborne pathogens and antibiotic-resistant bacteria. His work encompasses the development of novel antimicrobials, elucidation of antibiotic resistance mechanisms and the advancement of bacteriophage therapy. He also conducts surveillance and epidemiological investigations of antibiotic resistance, complemented by in-depth analyses of the microbiome and resistome. Further, his research examines the dissemination of antibiotic resistance throughout the food supply chain and addresses broader challenges at the intersection of food safety and human health.
Education
- PhD
- Food Science, The Ohio State University
- MS
- Plant and Soil Science, Southern Illinois University Carbondale
- MS
- Fermentation Engineering, South China University of Technology
- BS
- Food Science, Southwest University, China
Research interests
Antibiotic resistance, Food microbiology and safety, New antimicrobial drug discovery, Bacteriophage
Additional background
Patents
- Huang E., Moon S.H., Smeltzer M.S., and Meeker D.G. 2022. Linear lipopeptide paenipeptins and methods of using the same. Patent number: US 11,364,275 B2
- Yousef A.E., Guo Y., Huang E., Yuan C., and Zhang L. 2011. Antimicrobial agent, bacterial strain, biosynthesis, and methods of use. Patent number: US 9,017,692 B2
Select publications
- Huang, E., Thompson, R. N., Moon, S. H., Keck, J. M., Lowry, M. S., Melero, J., ... & Dare, R. K. (2024). Treatment-emergent cefiderocol resistance in carbapenem-resistant Acinetobacter baumannii is associated with insertion sequence ISAba36 in the siderophore receptor pirA. Antimicrobial Agents and Chemotherapy, e00290-24. https://doi.org/10.1128/aac.00290-24
- Moon, S. H. and Huang, E. (2023). Cefiderocol resistance in Klebsiella pneumoniae is linked to SHV extended-spectrum β-Lactamase activities and functional loss of the outer membrane porin OmpK35. Microbiology Spectrum, 03496-22. https://doi.org/10.1128/spectrum.03496-22
- Huang, E., Yang, X., Leighton, E., Li, X. (2023). Carbapenem resistance in the food supply chain. Journal of Food Protection, 100108. https://doi.org/10.1016/j.jfp.2023.100108
- Moon S.H., Udaondo Z., Abram K.Z., Li X., Yang X., DiCaprio E.L., Jun S.R., Huang E. 2022. Isolation of AmpC- and extended spectrum β-lactamase-producing Enterobacterales from fresh vegetables in the United States. Food Control, 132, 108559. https://doi.org/10.1016/j.foodcont.2021.108559
- Moon S.H., Kaufmann Y., Huang E. 2020. Paenipeptin analogues potentiate clarithromycin and rifampicin against mcr-1 mediated polymyxin-resistant Escherichia coli in vivo. Antimicrobial Agents and Chemotherapy, 64 (4), e02045-19. https://doi.org/10.1128/AAC.02045-19
- Moon S.H., Zhang X., Zheng G., Meeker D.G., Smeltzer M.S., Huang E. 2017. Novel linear lipopeptide paenipeptins with potential for eradicating biofilms and sensitizing Gram-negative bacteria to rifampicin and clarithromycin. Journal of Medicinal Chemistry, 60, 9630-9640. https://doi.org/10.1021/acs.jmedchem.7b01064