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Background:
My main theme of research is microbial contamination in environments that leads to human exposure and its linkage to health outcome. I am focusing on understanding pathways of microbial transmission, microbial dynamics and interactions within microbial community in multi-temporal and spatial scales, and effects on gastrointestinal illness and cancers. My lab has focused on several areas in water and food matrices (see Research Interests) and has studied enteric bacteria and viruses, cyanobacteria, cyanotoxins, and antibiotic resistance using interdisciplinary approach, including metagenomic, metabolomic and geospatial tools.
Research Interests:
- Cyanotoxin exposure and health risks,
- Cyanobacteria, cyanophage, and toxin ecology,
- Microbiome & resistome in environments and hosts,
- Food-water-climate nexus & emerging infectious diseases,
- Zoonotic pathogens: transmission dynamics between domains and human health,
- Sustainable intervention of pathogen and antibiotic resistance spread,
- Linkage between public health and ecosystem health,
- Urban water microbiology,
- Microbial source tracking
Education:
Awards/Honors:
Selected Publications:
2019
Briland, R, Stone, J, Manubolu, M, Lee, J, Ludsin, S. 2019. Cyanobacterial blooms modify food web structure and interactions in western Lake Erie. Harmful Algae. (In press)
Malloy, S, Newton, E, Horack, J, Lee, J. 2019. Earth observation for public health: Biodiversity change and emerging disease surveillance. Acta Astronautica.160:433-441. https://www.sciencedirect.com/science/article/pii/S0094576518302479
Klase, G, Lee, S, Liang, S, Kim, J, Zo, Y-G, Lee, J. 2019. The Microbiome and Antibiotic Resistance in Integrated Fishfarm Water: Implications of Environmental Public Health. Science of the Total Environment. 649:1491-1501. https://www.sciencedirect.com/science/article/pii/S0048969718332571
Hu, C, Lee, J. 2019. A novel proof-of-concept sandwich immunoassay for screening free microcystin in cyanobacteria based on Michael addition reaction. Analytical Sciences. 35(1):107-111. https://www.ncbi.nlm.nih.gov/pubmed/30298821
2018
Mrdjen, I, Morse, MA, Ruch, RJ, Knobloch, TJ, Choudhary, S, Weghorst, CM, Lee, J. 2018. Impact of Microcystin-LR on Liver Function Varies by Dose and Sex in Mice. Toxins. 10(11):435. https://www.ncbi.nlm.nih.gov/pubmed/30373283
Woroszylo, C, Choi, B, Profitos, JH, Lee, J, Garabed, R, Rempala, G. 2018. Modeling household transmission dynamics: Application to waterborne diarrheal disease in Central Africa. PLoS One. 13(11):e0206418. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206418
Mrdjen, I, Fennessy, S, Schaal, A, Dennis, R, Slonczewski, JL, Lee, S, Lee J. 2018. Tile Drainage and Anthropogenic Land Use Contribute to Harmful Algal Blooms and Microbiota Shift in Inland Water Bodies. Environmental Science & Technology. 52(15):8215-8223. https://www.ncbi.nlm.nih.gov/pubmed/29952549
Hu, C, Ludsin, S, Martin, J, Dittmann, E, Lee, J. 2018. Mycosporine-like amino acids (MAAs) - producing Microcystis in Lake Erie: Development of a qPCR assay and insight into its ecology. Harmful Algae. 77:1-10. https://www.ncbi.nlm.nih.gov/pubmed/30005796
Mrdjen, I, Lee, J. 2018. Simple and practical on-site treatment of high microcystin levels in water using polypropylene plastic. Journal of Environmental Science and Health, Part A.53(11): 1000-1005. https://doi.org/10.1080/10934529.2018.1471032
Manubolu, M, Lee, J, Riedl, KM, Kua, ZH, Collart, LP, Ludsin, SA. 2018. Optimization of extraction methods for quantification of microcystin-LR and microcystin-RR in fish, vegetable, and soil matrices using UPLC–MS/MS. Harmful Algae. 77:1-10.
Danner, K, Mave, M, Sawyer, A, Lee, S. Lee, J. 2018. Removal of the algal toxin microcystin-LR in permeable coastal sediments: physical and numerical models. Limnology and Oceanography. (Epub ahead of print) https://doi.org/10.1002/lno.10794
Potekin, R, Dharmasena, S, Keum, H, Jiang, X, Lee, J, Kim, S, Bergman, L, Vakakis, A, Cho, H. 2018. Multi-frequency Atomic Force Microscopy Based on Enhanced Internal Resonance of an Inner-Paddled Cantilever. Sensors & Actuators: A. Physical. 273:206-220. https://doi.org/10.1016/j.sna.2018.01.063
Marion, J, Lee, J, Rosenblum, J, Buckley, T. 2018. Assessment of temperature and UV radiation effects on sunburn incidence at an inland US Beach: a Cohort Study. Environmental Research. 161:479-484.
Rosenblum, J, Lee, J, Martin, J, Bisesi, M. 2018. Correlation between levels of Humic Acid and Fecal Indicator Bacteria: A Potential Predictor of Biosolids Stabilization? Environmental Engineering Science. 35:7:1-10.
2017
Lee, S, Jiang, X, Manubolu, M, Riedl, K, Ludsin, S, Martin, J, Lee, J. 2017. Cyanotoxin from Irrigation Water Accumulates in Fresh Produce and Soil: Implications for Public Health and Food Security. Food Research International. 102: 234-245. https://www.ncbi.nlm.nih.gov/pubmed/29195944
Lee, J, Lee, S, Jiang, X. 2017. Cyanobacterial Toxins in Freshwater and Food: Important Sources of Exposure to Humans. Annual Review of Food Science and Technology. 8:281-304. http://www.annualreviews.org/doi/abs/10.1146/annurev-food-030216-030116
Zhang, F, Hu, C, Shum, CK. Liang, S, Lee, J. 2017. Satellite remote sensing of drinking water intakes in Lake Erie for cyanobacteria population using two MODIS-based indicators as a potential tool for toxin tracking. Frontiers in Marine Science. 4:124. https://www.frontiersin.org/articles/10.3389/fmars.2017.00124/full
Gorham, T, Jia, Y, Shum, CK, Lee, J. Ten-Year Survey of Cyanobacteria Blooms in Ohio’s Waterbodies Using Satellite Remote Sensing. Harmful Algae. 66:13-19. https://www.sciencedirect.com/science/article/pii/S1568988316303596?via%...
Tian, D, Xie, G, Tian, J, Tseng, S, Shum, C.K, Lee, J, Liang, S. 2017. Spatiotemporal variability and environmental factors of harmful algal blooms (HABs) over western Lake Erie. PLoS One. 12(6):e0179622. https://doi.org/10.1371/journal.pone.0179622
Wituszynski, D, Hu, C, Zhang, F, Chaffin, J, Lee, J, Ludsin, S, Martin, J. 2017. Microcystin in Lake Erie fish: Risk to human health and relationship to cyanobacterial blooms. Journal of Great Lakes Research. 43:6:1084-1090.
Marion, J, Zhang, F, Cutting, J, Lee, J. 2017. Associations between county-level land cover classes and cyanobacteria blooms in the United States. Ecological Engineering. 108:5556-563. https://www.sciencedirect.com/science/article/pii/S0925857417304482
Jiang, X, Lee, S, Mok, C, Lee, J. 2017. Sustainable Methods for Decontamination of Microcystin in Water using Cold Plasma and UV with Reusable TiO2 Nanoparticle Coating. International Journal of Hygiene and Environmental Health. 14(5):480. https://www.ncbi.nlm.nih.gov/pubmed/28475156
Hsu, T-T D, Martin, J, Mitsch, W, Lee, J. Towards sustainable protection of public health: The role of urban wetlands as a frontline safeguard of pathogen and antibiotic resistance spread. Ecological Engineering. 108:547-555. https://www.sciencedirect.com/science/article/pii/S0925857417301180
Gorham, T, Yoo, J, Garabed, R, Mouhaman, A, Lee, J. 2017. Water Access, Sanitation and Hygiene Conditions and Health Outcomes among Two Settlement Types in Rural Far North Cameroon. International Journal of Hygiene and Environmental Health. 14(4):441 https://www.ncbi.nlm.nih.gov/pubmed/28425935
Gupta, M, Bisesi, SM, Lee, J. 2017. Comparison of survivability of Staphylococcus aureus and spores of Aspergillus niger on commonly used floor materials. American Journal of infection control.45(7):717-722. https://www.ncbi.nlm.nih.gov/pubmed/28318645
Borherova, Z, Park, E, Holloran, K, Lee, J. 2017. Water quality changes shortly after low-head dam removal examined with cultural and microbial source tracking methods. River Research and Application. 33:113-122.
2016
Lee, S, An, R, Grewal, P, Yu, Z, Borherova, Z, Lee, J. 2016. High Performing Windowfarm Hydroponic System: Transcriptomes of Fresh Produce and Microbial Communities in Response to Beneficial Bacterial Treatment. Molecular Plant-Microbe Interactions. 29(12):965-976.
Lee, CS, Kim, M, Yu, Z, Lee, J. 2016. The Microbiota of Recreational Freshwaters and the Implications of Environmental and Public Health. Frontiers in Microbiology. 7:1826. https://www.frontiersin.org/articles/10.3389/fmicb.2016.01826/full
Park, E, Mancl, K, Tuovinen, O, Bisesi, M, Lee, J. Ensuring safe reuse of residential wastewater: Reduction of microbes and genes using peat biofilter and batch chlorination in an on-site treatment system. Journal of Applied Microbiology. 121:1777-1788.
Healy, J, Piperata, P, Moritz, M, Lee, J, Garabed, R, Gundich, M, Mouhaman, A, Ahmadou M, Lee, S. 2016. One Health Research in Cameroon: A Critical Role for Anthropologists. Practicing Anthropology. 38(4):27-30.
Healy, J, Lee, S, Mouhaman, A, Garabed, R, Moritz, M, Piperata, P, Lee, J. 2016. Neighborhood diversity of potential pathogenic bacteria in drinking water from the city of Maroua, Cameroon. Journal of Water and Health. 14(3):559-570.
Hu, C, Rea, C, Yu, Z, Lee, J, 2016. Relative importance of Microcystis abundance and diversity in determining microcystin dynamics in Lake Erie coastal wetland and downstream beach water. Journal of Applied Microbiology. 120(1):138-151
Hsu, T, Rea, C, Yu, Z, Lee, J. 2016. The prevalence and diversity of shiga toxin genes in Canada Geese and water in western Lake Erie region. Journal of Great Lakes Research. 42(2):476-481.
Mrdjen, I, Lee, J. 2016. High Volume Hydraulic Fracturing Operations: Potential Impacts on Surface Water and Human Health. International Journal of Environmental Health Research. 26(4):361-380.
Gorham, T, Lee, J, 2016. Pathogen loading from Canada geese feces in freshwater: potential risks to human health through recreational water exposure. Zoonoses and Public Health. 63:177-190.
2015
Lee, J, Tseng, K-H, Zhang, F, Lee, C, Marion, J, Liang, S, Shum, CK. 2016. From satellite to genes: An integrative approach for timely monitoring of harmful cyanobacteria in Lake Erie beaches. Journal of Environmental Pollution and Human Health. 3(3):70-79.
Zhang, F, Lee, J, Liang, S, Shum, CK. 2015. Cyanobacteria Blooms and Non-alcoholic Liver Disease: Evidence from a County Level Ecological Study in the United States. Environmental Health. 14:41 http://www.ehjournal.net/content/14/1/41
Lee, C, Marion, J, Cheung, M, Lee, CS, Lee, J, 2015. Associations among Human-Associated Fecal Contamination, Microcystis aeruginosa, and Microcystin at Lake Erie Beaches. International Journal of Environmental Research and Public Health. 12:11466-11485.
Hsu, T-T D, Lee, J, 2015. Global Distribution and Prevalence of Arcobacter in Food and Water. Zoonoses and Public Health. doi: 10.1111/zph.12215 (Epub ahead of print).
Lee, S, Lee, J, 2015. A Review of Beneficial Bacteria in Hydroponic Systems: Types and Characteristics of Hydroponic Food Production Methods. Scientia Horticulturae. 195:206-215.
Marion, J, Burrowes, V, Lee, C, Lee, J. 2015. Changes in Microbial Water Quality Associated with an Extreme Recreational Water Event in Ohio, United States. Water Quality, Exposure, and Health. (Epub ahead of print)
Lee, S, Bohrerova, Z, Grewal, P, Lee, J. 2015. Enhancing plant productivity while suppressing biofilm growth in a windowfarm system using beneficial bacteria and ultraviolet irradiation. Canadian Journal of Microbiology. 61:1-10
Rea, C, Bisesi, M, Mitsch, W, Andridge, R, Lee, J. 2015. Human Health-related Wetland Ecosystem services of avian-dense coastal wetlands. EcoHealth. 12:77-87.
Rosenblum, J, Bisesi, M, Castano, J, Tamkin, A, Ciotola, R, Lee, J, Martin, J. 2015. Influence of Seasonal Fluctuation and Loading Rates on Microbial and Chemical Indicators During Semi-Continuous Anaerobic Digestion. Environmental Technology. 36:10:1308-1318.
Pornsukarom, S, Patchanee, P, Erdman, M, Cray, PF, Wittum, T, Lee, J, Gebreyes, W. 2015. Comparative phenotypic and genotypic analyses of Salmonella Rissen that originated from Thailand and the United States food animal sources. Zoonoses and Public Health. 62:2:151-158.
2014
Marion, J, Lee, C, Lee, CS, Lemeshow, S, Wang, Q, Buckley, T, Saif, L, Lee, J. 2014. Integrating Bacterial and Viral Water Quality Assessment to Predict Swimming-Associated Illness at a Freshwater Beach. PLoS One.9(11):e112029.
Healy, J, Mouhaman, A, Lee, S, Garabed, R, Moritz, M, Piperata, B, Tien, J, Bisesi, M, Lee, J. 2014. Muddying the Waters: A New Area of Concern for Drinking Water Contamination in Cameroon. International Journal of Environmental Research and Public Health. 11:12454-12472.
Lee, CS, Lee, C, Marion, JW, Wang, Q, Saif, L, Lee, J. 2014. Occurrence of Human Enteric Viruses at Freshwater Beaches during Swimming Season and Its link to Water Inflow. Science of the Total Environment. 472:757-766.
Lutz, JK, Crawford, JM, Wilkins III, JR, Lee, J, van-Balen, J, Nava-Hoet, RC, Hoet, AE. 2014. Methicillin-resistant Staphylococcus aureus (MRSA) in Public Transportation Vehicles (buses): Another Piece to the Epidemiologic Puzzle. American Journal of Infection Control. 42:12:1285-1290.
Ge, C, Lee, C, Li, J, Kleinhenz, M, Gardner, D, Lee, J. 2014. Impact of extreme weather events and phytopathogen infection on internalization of Salmonella Typhimurium in lettuce. International Journal of Food Microbiology.168-169:24-31.
Ge, C, Rymut, S, Lee, C, Lee, J. 2014. Salmonella internalization in mung bean sprouts and pre- and post-harvest intervention methods in a hydroponic System. Journal of Food Protection. 77:5:752-757.
Ciotola, R, Martin, J, Tamkin, A, Castano, J, Rosenblum, J, Bisesi, M, Lee, J. 2014. The Influence of Loading Rate and Variable Temperatures on Microbial Communities in Anaerobic Digesters. Energies. 7:785-803.
Park, E, Lee, C, Bisesi, M, Lee, J. 2014. Efficiency of Peracetic acid in inactivating bacteria, virus and spores measured with ATP bioluminescence, qPCR, and culture-based methods. Journal of Water and Health. 12:1:13-23.
2013
Rosenblum, J, Castano, Juan, Lee, J, Martin, J, Bisesi, M. 2013. The impact of inoculums-substrate ratios on microbial levels during psychrophilic anaerobic digestion. Journal of Environmental Science and Engineering A2:625-636.
Ciotola, R, Martin, J, Castano, J, Lee, J, Michel, F. 2013. Microbial Community Response to Seasonal Temperature Variation in a Small-Scale Anaerobic Digester. Energies. 6:5182-5199.
B. Layton, Y. Cao, D. Ebentier, K. Hanley, L. Van De Werfhorst, D. Wang, T. Madi, R. Whitman, M. Byappanahalli, E. Ballesté, W. Meijer, A. Schriewer, Stefan Wuertz, R. Converse, R. Noble, S. Srinivasan, J. Rose, C. S. Lee, J. Lee, J. Shields, J. Stewart, G. Reischer, A. Farnleitner, C. Sinigalliano, R. Rodrigues, S. Lozach, M. Gourmelon, L. Peed, O. Shanks, J. Jay, T. Holden, A. Boehm, J. Griffith. 2013. Performance of human fecal-anaerobe-associated PCR-based assays in a multi-laboratory method evaluation study. Water Research. 47(18):6897-6908.
Lee CS, Lee J. 2013. Application of host-specific source tracking tools for rapid identification of fecal contamination in fresh produce by human and livestock. Journal of the Science of Food and Agriculture. 93:5:1089-1096.
Lutz J, Crawford J, Hoet A, Wilkins J, Lee J. 2013. Comparative performance of contact plates, electrostatic wipes, swabs, and a novel sampling device for the detection of Staphylococcus aureus on environmental surfaces. Journal of Applied Microbiology. 115:1:171-178.
Park S, Balasubramaniam VM, Sastry S, Lee J. 2013. Pressure-ohmic thermal sterilization: a feasible approach for the inactivation of Bacillus amyloliquefaciens and Geoacillus stearothermophilus spores. Innovative Food Science and Emerging Technologies.19:115-123.
Sinigalliano, C, J. Ervin, L. Van De Werfhorst, D. Wang, D. Wanless, L, J. Bartkowiak, B. Layton, M. Raith, A. Schriewer, K. Goodwin, J. Lee, C. Lee, A. Boehm, R. Noble, P. Holden, J. Jay, S. Wuertz, M. Byappanahalli, M. Sadowsky, W. Meijer, M. Gourmelon, J. Griffith, J. SantoDomingo. 2013. Multi-laboratory evaluations of the performance of Catellicoccus marimammalium PCR assays developed to target gull fecal sources. Water Research. 47(18):6883-6896.
Lee C, Marion J, Lee J. 2013. Development and application of a quantitative PCR assay targeting Catellicoccus marimammalium for assessing gull-specific fecal contamination at Lake Erie beaches. Science of the Total Environment. 454-455:1-8.
Ge C, Bohrerova Z, Lee J. 2013. Inactivation of internalized Salmonella Typhimurium in lettuce and green onion using combination of ultraviolet C irradiation and chemical disinfectants. Journal of Applied Microbiology. 114:5:1415-1424
Ge C, Lee C, Lee J. 2013. Localization of Viable Salmonella Typhimurium Internalized through the Surface of Green Onion during Pre-harvest. Journal of Food Protection. 76(4):568–574.
Cheung MY, Liang S, Lee J. 2013. Toxin-producing Cyanobacteria in Freshwater: A Review of their Problems, Impact on Drinking Water Safety, and Efforts for Protecting Public Health. Journal of Microbiology. 51:1:1-10.
Agidi S, Vedachalam S, Mancl K, Lee J. 2013. Rapid determination of fecal bacteria in an onsite wastewater reuse system with human-specific IMS/ATP and qPCR. Journal of Environmental Management. 115:167-174.
2012
Rosenblum J, Ge C, Bohrerova Z, Yousef A, Lee, J. 2012. Ozonation as a Clean Technology for Fresh Produce Industry and Environment: Sanitizer Efficiency and Wastewater Quality. Journal of Applied Microbiology. 113:4:837-845.
Lee C, Agidi S, Marion J, Lee J. 2012. Arcobacter in Lake Erie beach waters: an emerging gastrointestinal pathogen linked with human-associated fecal contamination. Applied and Environmental Microbiology. 778:16:5511-5519.
Ratphitagsanti W. Park E, Lee CS, Wu R-Y. A, Lee J. 2012. High-throughput detection of spore contamination in food packages and food powers using tiered approach of ATP bioluminescence and real-time PCR. LWT-Food Science & Technology. 46:1:341-348.
Ge C, Lee C, Lee J. 2012. The Impact of Extreme Weather Events on Salmonella Internalization in Lettuce and Green Onion. Food Research International. 45:2:1118-1122. 2012.
Ge C, Lee CS, Yu Z, Lee J. 2012. Comparison of Bacterial Profiles of Fish between Storage Conditions at Retails Using DGGE and Banding Pattern Analysis: Consumer’s Perspective. Food and Nutrition Sciences. 3:2:190-200.
Marion J, Lee J, Wilkins J, Lemeshow S, Lee C, Waletzko E, Buckley T. 2012. In Vivo Phycocyanin Flourometry as a Rapid Screening Tool for Predicting Elevated Microcystin Concentrations at Inland Beaches. Environmental Science &Technology. 46:8:4523-4531.
2011
Lutz, J, Lee, J. 2011. Prevalence and Antimicrobial Resistance of Pseudomonas aeruginosa in swimming Pools and Hot Tubs. International Journal of Environmental Research and Public Health. 8:554-564.
Lee, CS, Marion, J, Lee, J. 2011. A Novel genetic marker for the rapid detection of Bacteroides fragilis in beach water as a human-specific fecal indicator. Journal of Water and Health. 9:2:253-264. 2011.
Lee CS, Wetzel K, Wozniak D, Buckley T, Lee J. 2011. Development of a real-time PCR assay targeting the gyrB gene for rapid detection of Pseudomonas aeruginosa in water and aerosols. Journal of Applied Microbiology. 111: 4: 893-903. 2011.
Deininger RA, Lee J, Clark R. 2011. Rapid detection of bacteria in drinking water and water contamination case studies. Frontiers of Earth Science. 5:4: 378-389.
2010
Lee J, Lee CS, Hugnnin KM, Maute CJ, Dysko RC. 2010. Bacteria from drinking water supply and their fate in gastrointestinal tracts of germ-free mice: a phylogenetic comparison study. Water Research. 44:17:5050-5058.
Lee, J, Deininger, RA. 2010. Real-time determination of the efficacy of residual disinfection to limit wastewater contamination in a water distribution system using filtration-based luminescence. Water Environment Research. 82:5:475-478.
Lee, J, Deininger, RA. 2010. Rapid detection of enterococci in marine beach water by immunomagnetic capture and bioluminescence and its comparison with conventional methods. Journal of Environmental Health. 72:9:8-13.
Marion, J, Lee, J, Lemeshow, S, Buckley, T, 2010. Association of gastrointestinal illness and recreational water exposure at an inland U.S. beach. Water Research. 44:16:4796-4804.
Lee, CS, Lee, J. 2010. Evaluation of new gyrB-based real-time PCR system for the detection of B. fragilis as an indicator of human-specific fecal contamination. Journal of Microbiological Methods. 82:3:311-318.
Wetzel, K, Lee, J, Lee, CS, Binkley, M. 2010. Comparison of microbial diversity of edible flowers and basil grown with organic versus conventional methods. Canadian Journal of Microbiology. 56:11:943-951.
