Darryl B. Hood, PhD

Darryl B. Hood, PhD
Associate Professor
Environmental Health Sciences
Phone: 614-247-4941
Email: hood.188@osu.edu
CV: File DBHBiosketch-April 2018.docx
408 Cunz Hall
1841 Neil Ave
Columbus, OH 43210

Background:

Darryl B. Hood, Ph.D. is an Associate Professor and environmental neuroscientist in the Division of Environmental Health Sciences in the College of Public Health at The Ohio State University. Dr. Hood received a BS degree in Biology and Chemistry from Johnson C. Smith University in Charlotte, NC. and a Ph.D. in Biochemistry from the Quillen-Dishner College of Medicine at East Tennessee State University. After completing a nearly 4-year postdoctoral fellowship at the Center in Molecular Toxicology at Vanderbilt University School of Medicine in 1993, Dr. Hood accepted a position at Meharry Medical College and served meritoriously until 2013 on the faculty of both Meharry Medical College and Vanderbilt University School of Medicine in the Department of Pharmacology and Neuroscience. During this he received over $11.2 million dollars of research funding.  The initial project in 1994 at Meharry Medical College was entitled "Acute and Sub-chronic Toxicity of Benzo(a)pyrene and Fluoranthene in F-344 rats,” and funded was at the level of $2.4 million dollars by the Minority Health Professions Foundation and Agency for Toxic Substances and Disease Registry. This project generated considerable interest from NIH and he wrote the competitive renewal in 1997 entitled “Multigenerational Effects of Inhaled B(a)P on Development” that was subsequently funded through 2002 at the level of $2.1 million dollars. These two projects served as the impetus for the development of an independent, investigator-initiated research program where the long-term goal was to determine the operative mechanisms in exposure-induced dysregulation of central nervous system development to impact learning and memory processes. He then wrote a grant entitled "Environmental Ah Receptor Agonists and Cognition" that funded my laboratory at the level of $1.9 million dollars from 2001 through 2006 that was part of a larger $5.4 million dollar Meharry Medical College initiative sponsored by the Office of Minority Health via the Specialized Neuroscience Research Program (SNRP) from the National Institute of Neurological Diseases and Stroke. From 2006-2011, Dr. Hood led what has come to be known as the most successful Minority S11 NIEHS-sponsored initiative referred to as the “Advanced Research Cooperation in Environmental Health (ARCH) Program. The specific title of this program project-like activity was “Mechanisms of Polycyclic Aromatic Hydrocarbon Toxicity”. The research conducted under this consortium ultimately contributed to the scientific database that the USEPA used to reassess the levels of polycyclic aromatic hydrocarbon emissions from smokestacks. Such re-assessments have resulted in public policy changes that will serve to decrease the adverse health effects associated with environmental exposures. The Meharry Medical College-Vanderbilt University ARCH Consortium was recognized as being at the interface of successful P01-like research programs in general, and for systems toxicology research, in particular. This construct served as the template that NIH Director, Dr. Elias A. Zerhouni used as the viable, futuristic model for the development of effective scientist-to-scientist interactions between research-intensive universities and historically black colleges and universities.

At the Ohio State University, Dr. Hood has continued his innovation in discovery as the co-architect of the novel Public Health Exposome framework. This paradigm altering framework interrogates hypotheses focused on determining if there are associations between the built, natural and social environment and disparate health outcomes observed in vulnerable populations. Dr. Hood’s overall contributions to science have resulted in confirmation that common environmental contaminants such as benzo(a)pyrene can have direct, negative impacts on the developmental expression of key regulators of glutamatergic signaling with associated negative impacts on behavioral learning and memory processes. His cumulative work of over two decades was recently recognized by the USEPA in the 2017 Integrated Risk Information System Assessment (IRIS) for the environmental contaminant benzo(a)pyrene [B(a)P] which cited multiple articles from his laboratory as a basis for recalibrating the reference concentrations (RfC) for inhaled B(a)P exposures in reproductive and neuro-toxicity studies. This represents a significant public policy change. Additionally, at The Ohio State University Dr. Hood has continued his robust environmental justice work in in the high risk and vulnerable underrepresented minority communities of Columbus, OH. Collectively, Dr. Hood has 105 peer-reviewed publications including book chapters and has mentored over 15 MSPH/MPH, 15-PhD and 9-Postdoctoral fellows. He continues to serve on numerous editorial and review boards for scientific journals, government agencies, and academia. Most recently, (2010-2016) he served on the US EPA Exposure and Human Health Subcommittee of the Science Advisory Board.  Recently, he was elected President of Toxicologists of African Origin, a Society of Toxicology special interest group which he covets as a very special honor.

Dr. Hood's Media

June 11, 2012

The Washington Times

https://www.scribd.com/document/176620798/Sometimes-environmental-justic...

April 6, 2016

South Side Voice last week concerning the Stambaugh-Elwood community.|The Columbus Dispatch

http://www.allthingssouth.org/uploads/1/1/0/8/11082676/ssv_april2016_web...

April 9, 2016

Diversity in Public Health Summit: Homelessness, Giving a Voice to an Underserved Population

http://www.ohiounionphotos.org/Student-Organizations/Student-Org-Events-...

April 22, 2016

Debt, pollution costs sinking Columbus Castings|The Columbus Dispatch

http://www.dispatch.com/content/stories/business/2016/04/21/debt-polluti...

May 11, 2015

Neighbors of South Side factories are fed up with toxic waste | The Columbus Dispatch

http://www.dispatch.com/article/20150511/NEWS/305119769

July 14, 2015

South Side soil study finds possible toxins, raises questions | The Columbus Dispatch

http://www.dispatch.com/article/20150714/NEWS/307149779

July 23, 2015

Rigorous testing needed on soil samples | The Columbus Dispatch

http://www.dispatch.com/content/stories/editorials/2015/07/23/1-rigorous...

September 2, 2015

Toxin levels in soil worry South Side neighborhood more than researchers| The Columbus Dispatch

http://www.dispatch.com/content/stories/local/2015/09/02/toxin-levels-in...

 Additional Links

http://mappler.info/ohio

http://engage.osu.edu/?q=events/public-health-presentation.html

http://www.toxicology.org/groups/sig/tao/

http://www.nationwidechildrens.org/perinatal-brain-injury-and-developmen...

http://www.toxicology.org/isot/sig/tao/officers.asp

 

Research Interests:

Inhalation Toxicology (prenatal exposure models autism), Developmental neurobiology (somatosensory cortex), Behavioral neurobiology (development of structure-specific paradigms), Environmental and biochemical toxicology (Nitroxides, PAH’s), Dispersion modeling of PAH’s in environmental justice communities, Structural biology, protein structure and function, Environmental-exposure health assessment questionnaire development, Modeling exposures across lifetime using public health exposome approach

Education:

Postdoc, Vanderbilt University School of Medicine, Dept. of Biochemistry and Center in Molecular Toxicology, Biophysics/ Molecular Toxicology, 1990-1994
Ph.D., East Tennessee State University, James H. Quillen College of Medicine, Biomedical Science/Biochemistry, 1990
B.S., Johnson C. Smith University, Biology/Chemistry, 1985

Selected Publications:

Chen CK, Bruce M, Tyler L, Brown C, Garrett A, Goggins S, Lewis-Polite B, Weriwoh ML, Juarez PD, Skelton T, Hood DB. (2013) Analysis of an environmental exposure health questionnaire in a metropolitan minority population utilizing logistic regression and support vector machines. J Health Care Poor Underserved. Feb; 24 (1 Suppl):153-171. doi: 10.1353/hpu.2013.0046. PMID: 23395953

Robinson PL, Dominguez F, Teklehaimanot S, Lee M, Brown A, Goodchild M, Hood DB. (2013) Does distance decay modeling of supermarket accessibility predict fruit and vegetable intake by individuals in a large metropolitan area? J Health Care Poor Underserved. Feb; 24 (1 Suppl):172-185. doi: 10.1353/hpu.2013.0049.PMID: 23395954

Mejia de Grubb MC, Kilbourne B, Kihlberg C, Levine RS, Hood DB. (2013) Demographic and geographic variations in breast cancer mortality among U.S.hispanics. J Health Care Poor Underserved. Feb; 24 (1 Suppl):140-152. doi: 10.1353/hpu.2013.0043. PMID: 23395952

Rehr R, Wilson S, Hood DB. (2013) The Maryland commission on environmental justice and sustainable communities: a review. J Health Care Poor Underserved. Feb; 24 (1 Suppl):129-139. doi: 10.1353/hpu.2013.0040. PMID: 23395951

Developing a cadre of transdisciplinary health disparities researchers for the 21st Century. Matthews-Juarez P, Jack L, Kennedy K, Hood DB. (2013) J Health Care Poor Underserved. Feb; 24(1 Suppl):121-128. doi: 10.1353/hpu.2013.0037. PMID: 23395950

Juarez P, Hood DB. Sequencing the public health genome. (2013) J Health Care Poor Underserved. Feb; 24(1 Suppl):114-20. doi: 10.1353/hpu.2013.0035. PMID: 23395949

Diggs D, Myers J, Banks LD, Hood DB, Roberts LJ, Ramesh A. (2013) Influence of dietary fat on benzo(a)pyrene biotransformation in a B(a)P-induced mouse model of colon cancer. Journal of Nutritional Biochemistry (in press)

Juarez PD., Hood DB, Im W, Levine RS, Matthews-Juarez P, Agboto V, Al-Hamdan M, Crosson WL, Estes MG, Estes S, Kilbourne B, Langston ML, Lichtveld M, Robinson P, Samaniego V, Woods C, Kilbourne K, Skelton T (2013) The Public Health Exposome: A Health Disparities Exposure Science Paradigm. American Journal of Public Health (in review)

Agboto VK; Langston ML; Juarez P; Matthews-Juarez P; Hood DB; Ding Tan; Rust GD, Maboudou-Tchao E, Kilbourne B; Sanderson M; Pisu M, Levine RS. (2013) A method for systematic community selection in evaluating breast cancer interventions: The use of mortality data. American Journal of Epidemiology (in review)

McCallister MM, Jules GE, Maguire M, Ramesh A, Newland MC, Hood DB. (2013) Identification and characterization of later-life spatial discrimination deficits subsequent to in utero exposure to benzo(a)pyrene aerosol. Toxicol. Sci. (in review)